Pathway: ceramide biosynthesis

Ceramide receives a lot of attention as a potential endogenous mediator of apoptosis in response to cytokines, antigens, anticancer drugs, or environmental stress inducers |CITS: [10652518]|. These diverse stimuli can induce sphingomyelin hydrolysis accompanied by the accumulation of ceramide, which occurs before morphological changes. In addition, administration of exogenous ceramide analogs can mimic apoptotic cell death. These observations led to the proposal that ceramide has a key role in apoptosis signaling |CITS: [12531549]|.

Protein: CEGT_HUMAN

Ceramide glucosyltransferase

FUNCTION: Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase". CATALYTIC ACTIVITY: UDP-glucose + N-acylsphingosine = UDP + D- glucosyl-N-acylsphingosine. less...

PATHWAY: Lipid metabolism; sphingolipid metabolism.

SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein (By similarity).

TISSUE SPECIFICITY: Found in all tissues examined.

SIMILARITY: Belongs to the glycosyltransferase 2 family. WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/";

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.